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First Issue #23 - April 2006
Last #41 - December 2007
Continued from Marvel Knights Spider-Man
Strange changes are coming over Spidey's animalistic foes - including Dr. Curt Connors, John Jameson, and Felicia Hardy?awakening the beast that dwells within them all. Sure, Spidey's beaten the Lizard, Man-Wolf, and The Black Cat before, but they've never been more vicious than they are now!