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Sales Rank #199 See Top 2,500
First Issue #1 - November 1992
Last #46 - August 1996
Continued in Spider-Man 2099 (2014 series)
Set a century in the future, the hero of Spider-Man 2099 was Miguel O'Hara, a Latino who works for Alchemax, a drug company with corrupt board members. O'Hara winds up the guinea pig in a risky genetic experiment and gets his DNA spliced with the genes of a Spider. Now infused with superpowers, he dons a costume based on the 'Day of the Dead' Mexican holiday. More than just another guy in a spider costume, O'Hara's DNA has been genetically altered -- he has venom glands and sharp fangs.